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KMID : 0381219860180020122
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Journal of RIMSK
1986 Volume.18 No. 2 p.122 ~ p.128
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Influence of Antibiotics on Human Milk Secretion
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Abstract
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The puerperium is the most highly medicated stage of pregnancy. In a survey of drugs prescribed in an obstetric service, it was found that two-thirds of all the drugs used were given to women in the puerperium, mostly in the week following birth of the child. Analgesics and sedatives were the most commonly prescribed drugs but significant quantities of antibiotics, anticoagulants and laxatives were also used.
The most of the puerpara who had antibiotics during the early postpartum period complain of the insufficient secretion of breast milk. This study aims to evaluate the influence of antibiotics on the serum prolactin levels and postpartum lactation. 100 healthy puerperal women were selected among the patient who delivered at term at the Department of Obstetrics and Gynecology Chungang University from April 1985 to March 1986.
To compare the serum prolactin levels and secretion of breast milk, patients were divided into five groups: normal control group, penicillin group, cephalosporin group, aminoglycoside group and combination group.
Each group consisted of 20 patients. The blood samples were taken at the 2nd and l0th
postpartum day. Prolactin was determined by radioimmunoassay(Abbott-Laboratory, USA). The degree of milk secretion was measured during the postpartum 10 days. The results were as follow:
1) Mean serum prolactin levels at the 2nd and 10th postpartum day of normal control group were 447.0±221.0 ng/ml and 210.4±50.4 ng/ml respectively. The degree of milk secretion was I (marked) 7 cases, II (moderate) 9 cases, III (mild) 3 cases and IV (no milk) 1 case in the normal control group.
2) Mean serum prolactin levels of penicillin group were 430.4±203.4 ng/ml and 243.5±146.9 ng/ml respectively. The degree of milk secretion was I (marked) 8 cases, II (moderate) 9 cases, III (mild) 3 cases, IV (no milk) absent in the penicillin group.
3) Mean serum prolactin levels of cephalosporin group were 408.0±187.2 ng/ml and 192.4 ±71.4 ng/ml respectively.
The degree of milk secretion was I (marked) 6 cases II (moderate) 9 cases, IV (mild) 4
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